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IGA NEPHROPATHY

(IgAN)

IgA Nephropathy is the most prevalent form of glomerulonephritis in the world.

4-HIT HYPOTHESIS

The multi-step model provides a testable model of pathogenetic processes in IgAN and a basis for development of disease-specific biomarkers and therapeutics.
---- Jan Novak, PhD ----

RG_4Hit_Elements-Gd-IgA1.png

HIT 1:

Increased Gal-deficient IgA1 (Gd-IgA1)
*The GalD Assay*

RG_4Hit_Elements-Anti-Glycan.png

HIT 2:

Production of unique Gd-IgA1-specific antibodies

RG_4Hit_Elements-Complexes_edited.png

HIT 3:

Formation of pathogenic immune complexes

RG_4Hit_Elements-KidneyInjury.png

HIT 4:

Glomerular deposition leads to kidney injury

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